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SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes

✍ Scribed by Jelena Kocic; Diana Bugarski; Juan F. Santibanez

Book ID
116430832
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
793 KB
Volume
48
Category
Article
ISSN
0959-8049

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Transforming growth factor ␤ 1 (TGF-␤ 1 ) is a stimulator of malignant progression in mouse skin carcinogenesis. TGF-␤ 1 exerts a differential effect on cultured nontumorigenic (MCA3D cell line) and transformed (PDV cell line) keratinocytes. Whereas MCA3D cells are growth arrested and committed to d