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Smad-Independent Transforming Growth Factor-β Regulation of Early Growth Response-1 and Sustained Expression in Fibrosis: Implications for Scleroderma

✍ Scribed by Swati Bhattacharyya; Shu-Jen Chen; Minghua Wu; Matthew Warner-Blankenship; Hongyan Ning; Gabriella Lakos; Yasuji Mori; Eric Chang; Chihiro Nihijima; Kazuhiro Takehara; Carol Feghali-Bostwick; John Varga


Book ID
117970816
Publisher
American Society for Investigative Pathology
Year
2008
Tongue
English
Weight
864 KB
Volume
173
Category
Article
ISSN
0002-9440

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Expression of transforming-growth-factor
✍ Ester Piek; Ulrica Westermark; Marianne Kastemar; Carl-Henrik Heldin; E. Joop va 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 268 KB 👁 1 views

A panel of 6 human glioma cell lines was examined for TGF-␤1 responsiveness. U-178 MG and U-251 MG AgCl1 were significantly inhibited by TGF-␤1, while U-343 MGa 31L and U-343 MGa 35L were potently stimulated to proliferate. TGF-␤1 induced endogenous PAI-1 protein synthesis, Smad binding element/(CAG