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Slug expression during organogenesis in mice

✍ Scribed by Oram, Kathleen F. ;Carver, Ethan A. ;Gridley, Thomas

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
558 KB
Volume
271A
Category
Article
ISSN
0003-276X

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✦ Synopsis

Abstract

The vertebrate Slug gene encodes a zinc finger‐containing transcriptional repressor. Here we report expression of the mouse Slug gene during organogenesis and late fetal development using histochemical detection of β‐galactosidase expressed from a targeted Slug^lacZ^ knock‐in allele. The Slug gene is highly expressed in the mesenchymal or stromal component of numerous organs. It is also highly expressed in craniofacial mesenchyme, in bone of both mesodermal and neural crest origin, and in the outflow tract and the endocardial cushions of the heart. Anat Rec Part A 271A:189–191, 2003. Β© 2003 Wiley‐Liss, Inc.

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