Slower clearance of intravenous metformin in rats with acute renal failure induced by uranyl nitrate: Contribution of slower renal and non-renal clearances
β Scribed by Young H. Choi; Inchul Lee; Myung G. Lee
- Book ID
- 113592194
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 440 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0928-0987
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## Abstract In rats pretreated with dexamethasone (an inducer of CYP3A1/2 in rats) and troleandomycin (an inhibitor of CYP3A1/2 in rats), the area under the plasma concentrationβtime curve from time zero to time infinity (__AUC__) values of clarithromycin were significantly smaller (365 compared wi
The effects of glucose on CYP2E1 expression in rats with acute renal failure induced by uranyl nitrate (U-ARF) have been reported. CYP2E1 was significantly induced (2.3-fold) in rats with U-ARF compared with that in control rats. In contrast, CYP2E1 expression was significantly decreased in rats wit