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Slow α Helix Formation during Folding of a Membrane Protein †

✍ Scribed by Riley, M. Louise; Wallace, B. A.; Flitsch, Sabine L.; Booth, Paula J.


Book ID
126853165
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
110 KB
Volume
36
Category
Article
ISSN
0006-2960

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✍ Sosnick, Tobin R.; Jackson, Sharon; Wilk, Rosemarie R.; Englander, S. Walter; De 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 652 KB

To determine when secondary structure forms as two chains coalesce to form an alpha-helical dimer, the folding rates of variants of the coiled coil region of GCN4 were compared. Residues at non-perturbing positions along the exterior length of the helices were substituted one at a time with alanine