Slow release theophylline disposition and effect in elderly patients with chronic obstructive lung disease: Influence of dose formulation and institutionalization

✍ Scribed by Dr Patrick R. Montgomery; Fred Y. Aoki; Paul A. Mitenko; Michael Vanzieleghem; Daniel S. Sitar

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 431 KB
• Volume: 10
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510100506

✦ Synopsis

We studied the steady-state disposition of slow release theophylline tablets and granules in 12 institutionalized (I) and 12 community-dwelling (C) elderly patients with fixed chronic obstructive lung disease. Design was open label with random order crossover; each formulation was given 5 min before food every 12 h for 7 days. Age (median 70 y, range 55-88), sex, smoking status, and baseline lung function off drug were similar. Trough plasma concentration (C,) was higher with the tablets as was the area under the C, vs time curve: 134 (74-252) vs 121 (75-197) mghl-';p=0-028. The standard deviation of C, over one dose interval was lower with the granules. FEV1.O was slightly improved over baseline. Dose required to reach target C, was higher in the institutionalized roup vs C:68 (34-163); p0.003. Although biovailability was slightly reduced for the granules, fluctuations of C, was less, and we failed to find a food effect that was clinically important in geriatric subjects.