Slow-onset inhibition of ribosomal peptidyltransferase by lincomycin
โ Scribed by Sofia Kallia-Raftopoulos; Dimitrios L. Kalpaxis; Charalambos Coutsogeorgopoulos
- Book ID
- 115709194
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 777 KB
- Volume
- 298
- Category
- Article
- ISSN
- 0003-9861
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The antibiotic lincomyein is a specific inhibitor of chloroplast ribosomal activity in greening leaves of Pisum sativum at 1 ~zg/ml, and prevents both the formation of chloroplast membranes and their stacking into grana. This finding suggests that one function of chloroplast ribosomes is to synthesi
The effect of spermine on the binding of AcPhe-tRNA to poly(U)-programmed ribosomes (step 1) and on the puromycin reaction (step 2) has been studied in a cell-free system, derived from E. coli. In the absence of ribosomal wash (FWR fraction) and at suboptimal concentration of Mg++ (6 mM), spermine s