Slow clearance gadolinium-based extracellular and intravascular contrast media for three-dimensional MR angiography
✍ Scribed by Jens Bremerich; Jean Marie Colet; Giovanni Battista Giovenzana; Silvio Aime; Klaus Scheffler; Sophie Laurent; Georg Bongartz; Robert N. Muller
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 327 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The objective of this study was to assess two new slow‐clearance contrast media with extracellular and intravascular distribution for magnetic resonance angiography (MRA). Extracellular Gd‐DTPA‐BC~2~glucA and intravascular Gd(DO3A)~3~‐lys~16~ were developed within the European Biomed2 MACE Program and compared with two reference compounds, intravascular CMD‐A2‐Gd‐DOTA and extracellular GdDOTA, in 12 rats. Pre‐ and post‐contrast three‐dimensional MR (TR/TE = 5 msec/2.2 msec; isotropic voxel size 0.86 mm^3^) was acquired for 2 hours. Signal‐to‐noise enhancement (ΔSNR) was calculated. Two minutes after injection, all contrast media provided strong vascular signal enhancement. The ΔSNR for Gd‐DTPA‐BC~2~glucA, Gd(DO3A)~3~‐lys~16~, CMD‐A2‐Gd‐DOTA, and GdDOTA were 13.0 ± 1.8, 25.0 ± 3.2, 25.0 ± 4.0, and 18.0 ± 3.4, respectively. Gd‐DTPA‐BC~2~glucA, Gd(DO3A)~3~‐lys~16~, and CMD‐A2‐Gd‐DOTA cleared slowly from the circulation, whereas GdDOTA cleared rapidly. Vascular ΔSNR at 2 hours were 2.9 ± 0.6, 25.0 ± 3.2, 25.0 ± 4.0, and 0.4 ± 1.0. Gd(DO3A)~3~‐lys~16~ provided strong vascular and minor background enhancement, and thus may be useful for MRA or perfusion imaging. Gd‐DTPA‐BC~2~glucA produces persistent enhancement of extracellular water, and thus may allow quantification of extracellular distribution volume and assessment of myocardial viability. J. Magn. Reson. Imaging 2001;13:588–593. © 2001 Wiley‐Liss, Inc.