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Sleep: Effects ofd- andl-amphetamine in man and in rat

✍ Scribed by Ernest Hartmann; James Cravens

Publisher: Springer
Year: 1976
Tongue: English
Weight: 472 KB
Volume: 50
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00430488

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✦ Synopsis

Almost identical results are reported in man and in rat for the effects of the amphetamine isomers on polygraphically recorded sleep. In both species, dextro-amphetamine produces a significantly greater increase in waking time. In both species, the two isomers have equal effects in reducing desynchronized sleep time. These findings combined with other recent data suggest that dopamine plays a direct rolw in wakefulness while norepinephrine is related inversely to amolnts of desynchronized sleep.

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