Skin development and GAP junctional intercellular communication in a connexin 43 knockout mouse
โ Scribed by Choudhry, Rukhsana; Pitts, John D.; Hodgins, Malcolm B.
- Book ID
- 119562211
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 191 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0923-1811
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## Abstract The function of gap junctions is regulated by the phosphorylation state of their connexin subunits. Numerous growth factors are known to regulate connexin phosphorylation; however, the effect of nerve growth factor on gap junction function is not understood. The phosphorylation of conne
Astrocytes are characterized by extensive intercellular communication mediated primarily by gap junction channels composed of connexin43. To examine this junctional protein in astrocytic functions, astrocytes were cultured from embryonic mice with a null mutation in the connexin43 gene (Reaume et al