Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs
β Scribed by K.M. Dixon; S.S. Deo; G. Wong; M. Slater; A.W. Norman; J.E. Bishop; G.H. Posner; S. Ishizuka; G.M. Halliday; V.E. Reeve; R.S. Mason
- Book ID
- 116697663
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 286 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0960-0760
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## Abstract Retinoids, cytokines as well as 1,25βdihydroxyvitamin D~3~ [1,25(OH)~2~D~3~] and analogs possess properties known to contribute potentially to cancer chemopreventive and chemotherapeutic effects. They induce cell differentiation, inhibit cell prolifeation, suppress expression of viral o
The steroid hormone Ia,25-dihydroxyvitamin D3 has been shown to exert rapid effects (1 5 s to 5 min) in osteoblasts. These effects occur in osteoblast-like cells lacking the nuclear vitamin D receptor, ROS 24/1, suggesting that a separate signalling system mediates the rapid actions. These non-genom