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Skeletal muscle response to tenotomy

✍ Scribed by Amir A. Jamali; Pouya Afshar; Reid A. Abrams; Richard L. Lieber

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 450 KB
Volume: 23
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(200006)23:6<851::aid-mus3>3.0.co;2-a

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✦ Synopsis

Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central core necrosis, Z-line streaming, fibrosis of fibers and Golgi tendon organs, changes in sarcomere number, and alterations in the number of membrane particles. Molecular changes include transient changes in myosin heavy chain composition and expression of neural cell adhesion molecule (NCAM). Functionally, tenotomized muscle produces decreased maximum tetanic and twitch tension. Alterations in normal skeletal muscle structure and function are clinically applicable to the understanding of pathological states that follow tendon rupture and iatrogenic tenotomy.

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