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Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)

โœ Scribed by Frederick S. Kaplan; Qi Shen; Vitali Lounev; Petra Seemann; Jay Groppe; Takenobu Katagiri; Robert J. Pignolo; Eileen M. Shore

Publisher
Springer
Year
2008
Tongue
English
Weight
382 KB
Volume
26
Category
Article
ISSN
0914-8779

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## Abstract Cell surface heparan sulfate proteoglycans (HSPGs) play important roles in morphogen gradient formation and cell signaling. Bone morphogenetic protein (BMP) signaling is dysregulated in fibrodysplasia ossificans progressiva (FOP), a disabling disorder of progressive heterotopic bone for