Size of polymeric particles forming hemodialysis membranes determined from water and solute permeabilities
✍ Scribed by Toshiyuki Kanamori; Toshio Shinbo; Kiyotaka Sakai
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 157 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0021-8995
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✦ Synopsis
Regarding hemodialysis membranes as layers packed with uniform polymeric particles, the size of the particles is determined using the Kozeny-Carman equation. Diameter of the spheres forming cellulosic membranes is the same order as the size of primary polymeric particles determined by electron microscopy in a previous article. Pore radii of the membranes calculated by the Kozeny-Carman equation are in agreement with those determined by the tortuous capillary pore model. The result suggests that an estimate of a pore radius of a membrane is feasible by the Kozeny-Carman equation only with water permeability of the membrane. Intramembrane diffusion coefficients of vitamin B 12 calculated from an equation derived from the analogy of heat conduction in heterogeneous media consisting of a continuous phase and particles are larger than the experimental values. The result suggests the failure of the analogy between heat conduction and diffusion of vitamin B 12 in a heterogeneous medium.