Size-dependent increase in the levels of prota-glandin metabolites in adenomas of patients with familial adenomatous polyposis (FAP)
β Scribed by Yang, VW; Shields, JM; Hamilton, SR; Spannhake, EW; Hubbard, WC; Hylind, LM; Robinson, CR; Giardiello, FM
- Book ID
- 123465804
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 183 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0016-5085
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## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T