✦ LIBER ✦
Size-Controlled Formation of a Calcium Phosphate-Based Organic–Inorganic Hybrid Vector for Gene Delivery Using Poly(ethylene glycol)-block-poly(aspartic acid)
✍ Scribed by Y. Kakizawa; K. Miyata; S. Furukawa; K. Kataoka
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 132 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0935-9648
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✦ Synopsis
Poly(ethylene glycol) (PEG)‐covered hybrid particles (see Figure) of calcium phosphate (CaP), and plasmid DNA (pDNA) have been prepared in a size‐controllable manner in the presence of a block copolymer. The particles show a substantial colloidal stability as well as tolerance of entrapped pDNA against nuclease attack in the medium, and achieve a significantly higher gene expression compared to conventional precipitates.