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Six New Dammarane Triterpenoids from Viburnum cylindricum

✍ Scribed by Lin Tu; Yu Zhao; Zu-Yin Yu; Yu-Wen Cong; Gang Xu; Li-Yan Peng; Peng-Tao Zhang; Xiao Cheng; Qin-Shi Zhao

Publisher
John Wiley and Sons
Year
2008
Tongue
German
Weight
236 KB
Volume
91
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

One new dammarane triterpenoid, cylindrictone A (1), as well as five new nor‐dammarane triterpenoids cylindrictone B–F (2–6) were isolated from the leaves of Viburnum cylindrium, together with three known compounds 3__β__‐hydroxy‐hexanordammaran‐20‐one (7), 3__α__‐hydroxyoctanordammar‐12‐en‐17‐one (8), and neoalsogenin B (9). Their structures were identified by extensive NMR‐spectroscopic (especially 2D‐NMR) and mass‐spectrometric experiments, and the structure of 3 was further confirmed by a single‐crystal X‐ray analysis. The compounds exhibited no activity against human promyelocytic leukemia HL60 cell.

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