Six-month outcomes for MRI-related vascular depression

✍ Scribed by K. Ranga Rama Krishnan; Judith C. Hays; Linda K. George; Dan G. Blazer

• Book ID: 101296800
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 70 KB
• Volume: 8
• Category: Article
• ISSN: 1091-4269
• DOI: 10.1002/(sici)1520-6394(1998)8:4<142::aid-da2>3.0.co;2-n

✦ Synopsis

The purpose of this paper is to estimate the relative probabilities of 6-month recovery from an index episode of major depression for subjects with and without MRI-confirmed vascular brain changes. In this cohort study, 57 depressed subjects from the Duke University Mental Health Clinical Research Center (MHCRC) for Depression in Late Life who presented with MRI-related vascular and non-vascular depression were followed for 6 months, and the rates of recovery in the two risk groups were compared. Overall, the recovery rate in this sample was 57.9%. Subjects with MRI-related vascular depression demonstrated outcomes similar to subjects with non-vascular depression (crude RR=0.67[0.32,1.43]). There was a trend that demonstrated that MRI-related vascular depression placed elderly subjects and subjects with first onset of depression after age 40 at increased risk of non-recovery. The study demonstrates overall no significant difference in course between patients with and without vascular depression. It also suggests that patients with vascular depression may have a different course depending on their age and age of onset of the disease.