✦ LIBER ✦

Sites of B-cell activation in vivo

✍ Scribed by Garnett Kelsoe; Biao Zheng

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 578 KB
Volume: 5
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(93)90062-w

No coin nor oath required. For personal study only.

✦ Synopsis

Novel techniques have made possible in situ analyses of the lymphocyte populations responding to antigen. In the spleen, antigen-specific T and B cells are first observed in the periarteriolar lymphoid sheath. Following conjugate formation between specific T and B lymphocytes, B-cell proliferation and differentiation takes place in two distinct sites, the periarteriolar lymphoid sheath-associated foci and germinal centers.

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