## Abstract 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the most abundant heterocyclic amine derived from food, possibly involved in human carcinogenesis. We evaluated the formation of PhIP‐DNA adducts in lymphocytes from 76 incident colorectal cancer patients likely to be exposed
Site-specific mutagenesis of the N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine DNA adduct in mammalian cells
✍ Scribed by S. Shibutani; Andrea Fernandes; Naomi Suzuki; L. Zhou; Francis Johnson; Arthur P. Grollman
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 95 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0044-3026
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## Abstract 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) and 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__)]pyridine (PhIP) are two members of a family of carcinogenic heterocyclic amines (HAs) found in cooked meats that form DNA adducts after activation to __N__‐acetoxy derivatives. The ability of IQ
## Abstract 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (PhIP) is the most abundant mutagenic heterocyclic amine in cooked foods. Two mouse tumor cell lines, BMT11 and FM3A, were exposed to its proximate form, 2‐hydroxyamino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine (__N__‐OH‐PhIP). Fifty
2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3
## Abstract The distribution of the adducts of the cooked meat‐derived heterocyclic amines 2–amino‐3–methylimidazo 4,5–__f__lquinoline (a) and 2–amino‐1–methyl‐6–phenylimidazo[4,5–__b__]pyridine (a) was examined in the __supF__ gene of PSP 189 by a polymerase‐arrest assay using thermal‐cycle sequen