Site-specific drug delivery to the middle region of the small intestine by application of enteric coating with hypromellose acetate succinate (HPMCAS)

Site-specific drug delivery to the middl

Site-specific drug delivery to the middle-to-lower region of the small intestine reduces food–drug interactions that are responsible for low drug absorption in the fed state

✍ Fumié K. Tanno; Shinji Sakuma; Yoshie Masaoka; Makoto Kataoka; Toshio Kozaki; Ry 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB 👁 1 views

Food-drug interactions may reduce the bioavailability of drugs taken after meals (negative food effects). We designed enteric-coated tablets that start to disintegrate when they reach the middle-to-lower region of the small intestine, and examined whether they could reduce negative food effects in d