Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors

Thrombin Activates Transcription Factors

Thrombin Activates Transcription Factors Sp1, NF-κB, and CREB: Importance of the Use of Phosphatase Inhibitors during Nuclear Protein Extraction for the Assessment of Transcription Factor DNA-Binding Activities

✍ Christine Edmead; Chryso Kanthou; Omar Benzakour 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 120 KB

Thrombin, a serine protease, is an important effector of many cellular processes and has been shown to upregulate the expression of several genes. The mechanisms underlying thrombin-mediated regulation of gene transcription remain poorly understood. The original aim of this work was to study the eff