Site -specific deuteration or tritiation of benzo [b] thiophene and 1- methylindole analogs of biologically active indole derivatives (1)

✍ Scribed by T. R. Bosin; R. B. Rogers

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: French
• Weight: 271 KB
• Volume: 9
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2590090302

✦ Synopsis

Abstract

The site‐specific deuteration and tritiation of 1‐methylindole and benzo [b] ‐thiopheme analogs of biologically active indole derivatives has been achieved by use of the facile metalation of these heterocycles with n‐butyllithium and subsequent reaction with ^2^H~2~ or ^3^H~2~O. Metalation occurs at the 2‐position and site and extent of deuterium incorporation was determined by N. M. K. The use of similar procedures with ^3^H~2~ O led to ready incorporation of tritium into these heterocycles.