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Site-specific dehydrogenation of ring D in steroids

โœ Scribed by Baldwin, J. E.; Bhatnagar, A. K.; Harper, R. W.


Book ID
120625601
Publisher
Royal Society of Chemistry
Year
1970
Weight
265 KB
Volume
11
Category
Article
ISSN
0577-6171

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๐Ÿ“œ SIMILAR VOLUMES


Steroids, L. Ring D Cleavage of D-Trisub
โœ Vincze, Irรฉn ;Somlai, Csaba ;Schneider, Gyula ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 526 KB

## Abstract In alkaline medium, 17ฮฒโ€hydroxyโ€15โ€(hydroxymethylene)androstโ€5โ€enโ€16โ€one (2a) is cleaved in two ways to give Dโ€__seco__ compounds. Dilute bases in protic solvents cause 1,3โ€dicarbonyl splitting to the 15โ€formylโ€15,16โ€__seco__โ€16โ€oic acid 3, while the use of sodium methanolate in benzene