Site selective high resolution laser spectroscopy of europium in calcium binding proteins

High resolution, high-throughput amide d

High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and dynamics: Utility in pharmaceutical design

✍ Virgil L. Woods Jr.; Yoshitomo Hamuro 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 273 KB

Mass spectrometry-based peptide amide deuterium exchange techniques have proven to be increasingly powerful tools with which protein structure and function can be studied, and are unparalleled in their ability to probe sub-molecular protein dynamics. Despite this promise, the methodology has remaine