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Site-Selective DNA Hydrolysis by Combining Ce(IV)/EDTA with Monophosphate-Bearing Oligonucleotides and Enzymatic Ligation of the Scission Fragments

✍ Scribed by Chen, Wen; Kitamura, Yoshihito; Zhou, Jing-Min; Sumaoka, Jun; Komiyama, Makoto

Book ID: 120209376
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 121 KB
Volume: 126
Category: Article
ISSN: 0002-7863
DOI: 10.1021/ja048953a

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## Abstract __Two deoxyuridine derivatives each bearing a monophosphate group at the 5‐position with a C3 linker, were incorporated into an oligonucleotide. By using this modified oligonucleotide, a bulge was formed at a predetermined position in a DNA substrate, and two monophosphate groups were p