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Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1

✍ Scribed by Ruben J. Boado; Jian Yi Li; Chun Chu; Fumio Ogoshi; Petra Wise; William M. Pardridge

Book ID
116274048
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
336 KB
Volume
1715
Category
Article
ISSN
0005-2736

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Site-directed mutagenesis has been used to change amino acid residues of a recombinant Fc-hinge fragment derived from the murine immunoglobulin (1g)Gl molecule, and the effects of these mutations on the pharmacokinetics of the Fc-hinge fragment have been determined. Specifically, Ile-253, His-310 an