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Site dependent bioavailability and metabolism of levosimendan in dogs

โœ Scribed by Saila Antila; Hannele Huuskonen; Timo Nevalainen; Harri Kanerva; Paula Vanninen; Lasse Lehtonen


Book ID
114303229
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
197 KB
Volume
9
Category
Article
ISSN
0928-0987

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Oral and rectal nalbuphine bioavailabili
โœ Bruce J. Aungst; Gilbert Lam; Eli Shefter ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 370 KB ๐Ÿ‘ 2 views

The disposition of the narcotic antagonist/analgesic nalbuphine after i.v., oral, and rectal dosing was evaluated in rats and dogs. In both species nalbuphine had high systemic clearance and low oral bioavailability as a result of extensive first-pass metabolism. Administration to a closed 2 cm leng