Oral and rectal nalbuphine bioavailabili
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Bruce J. Aungst; Gilbert Lam; Eli Shefter
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Article
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1985
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John Wiley and Sons
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English
โ 370 KB
๐ 2 views
The disposition of the narcotic antagonist/analgesic nalbuphine after i.v., oral, and rectal dosing was evaluated in rats and dogs. In both species nalbuphine had high systemic clearance and low oral bioavailability as a result of extensive first-pass metabolism. Administration to a closed 2 cm leng