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Sister chromatid exchange in lymphoma lines and lymphoblastoid cell lines before and after heterotransplantation into nude mice

✍ Scribed by Christa Fonatsch; Hartmut H. Kirchner; Michael Schaadt; Manfred Günzel; Volker Diehl

Publisher: John Wiley and Sons
Year: 1981
Tongue: French
Weight: 368 KB
Volume: 28
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910280408

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✦ Synopsis

Abstract

The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant diseases were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosomal markers as well as chromosomally normal lymphoblastoid cell lines were used. The SCE frequencies of nude mouse tumor‐derived cell lines did not show a homogeneous pattern. They were either as high as, or higher or lower than, the SCE levels of the original cell line. But all cell lines, karyotypically abnormal as well as normal, originating from patients with malignant and premalignant diseases, showed significantly higher SCE rates than the control lines from healthy donors.

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Diploid human lymphoblastoid and burkitt

Diploid human lymphoblastoid and burkitt lymphoma cell lines: Susceptibility to murine NK cells and heterotransplantation to nude mice

✍ Kenneth J. McCormick; Beppino C. Giovanella; George Klein; Kenneth Nilsson; John 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 369 KB

## Abstract Human lymphoid cell lines which had been classified on the basis of studies on clonality and morphological, chromosomal and functional parameters as lymphoblastoid cell lines (LCL) of presumed non‐neoplastic origin and Burkitt lymphoma (BL) lines of proven malignant origin, were tested