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SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

โœ Scribed by Mao, Z.; Hine, C.; Tian, X.; Van Meter, M.; Au, M.; Vaidya, A.; Seluanov, A.; Gorbunova, V.


Book ID
119954121
Publisher
American Association for the Advancement of Science
Year
2011
Tongue
English
Weight
494 KB
Volume
332
Category
Article
ISSN
0036-8075

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## Abstract O^6^โ€methylguanineโ€DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylationโ€specific PCR (MSP)