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SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress

✍ Scribed by Patrizia D'Aquila; Giuseppina Rose; Maria Luisa Panno; Giuseppe Passarino; Dina Bellizzi

Book ID
116508709
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
361 KB
Volume
497
Category
Article
ISSN
0378-1119

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Several links exist between the two mechanisms of neuronal degeneration (i.e., oxygen radical production and mitochondrial damage) proposed to have a role in Parkinson's disease. Indeed, mitochondria are critical targets for the toxic injury induced by oxygen radicals, and experimental evidence sugg