Tumor necrosis factor Ξ±βmediated cleavag
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Mona Dvir-Ginzberg; Viktoria Gagarina; Eun Jin Lee; Richard Booth; Odile Gabay;
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Article
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2011
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John Wiley and Sons
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English
β 447 KB
## Abstract ## Objective The protein deacetylase SirT1 positively regulates cartilageβspecific gene expression, while the proinflammatory cytokine tumor necrosis factor Ξ± (TNFΞ±) negatively regulates these same genes. This study was undertaken to test the hypothesis that SirT1 is adversely affected