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SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression

✍ Scribed by Holloway, Kimberly R.; Barbieri, Andreia; Malyarchuk, Svitlana; Saxena, Madhurima; Nedeljkovic-Kurepa, Ana; Cameron Mehl, Mathieu; Wang, Allison; Gu, Xin; Pruitt, Kevin


Book ID
118738243
Publisher
Endocrine Society
Year
2013
Tongue
English
Weight
572 KB
Volume
27
Category
Article
ISSN
0888-8809

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Estrogen regulated expression of the p21
✍ Soma Mandal; James R. Davie πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 183 KB

## Abstract The cyclin‐dependent kinase inhibitor protein p21^Waf1/Cip1^ is a potent tumor suppressor. Here, we demonstrate that estradiol regulates the p21^Waf1/Cip1^ gene. Estradiol induces p21^Waf1/Cip1^ mRNA expression within 30–60 min independent of new protein synthesis in the estrogen recept