Sirolimus-associated Thrombotic Thrombocytopenic Purpura (TTP): Report of three cases and review of the literature
β Scribed by A.E. Eyzaguirre; R.B. Love; D.A. Hargate; R. Schilz
- Book ID
- 116518687
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 63 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1557-3117
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Three patients (one with idiopathic thrombocytopenic purpura [ITP] and two with thrombotic thrombocytopenic purpura [TTP]) were treated with rituximab (anti-CD20 chimeric antibody) at a dose of 325 mg/m 2 administered weekly after they failed standard therapies. The patient with ITP who did not resp
## Abstract Thrombotic thrombocytopenic purpura (TTP) is a severe lifeβthreatening hematological disorder affecting the microcirculation of multiple organ systems. Infection, pregnancy, cancer, drugs, and surgery are frequently associated with the initial episodes and relapses. Women who are either