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siRNA delivery with chitosan nanoparticles: Molecular properties favoring efficient gene silencing

✍ Scribed by Jostein Malmo; Hanne Sørgård; Kjell M. Vårum; Sabina P. Strand

Book ID
113694984
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
878 KB
Volume
158
Category
Article
ISSN
0168-3659

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We have previously introduced the use of the biomaterial chitosan to form chitosan/siRNA nanoparticles for gene silencing protocols. This present study shows that the physicochemical properties (size, zeta potential, morphology and complex stability) and in vitro gene silencing of chitosan/siRNA nan