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Sinus histiocytosis with massive lymphadenopathy. Report of a case associated with elevated EBV antibody titers

✍ Scribed by Marianne Lober; William Rawlings; Guy R. Newell; Richard J. Reed

Publisher: John Wiley and Sons
Year: 1973
Tongue: English
Weight: 450 KB
Volume: 32
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(197308)32:2<421::aid-cncr2820320220>3.0.co;2-d

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✦ Synopsis

A case of sinus histiocytosis with massive lymphadenopathy is reported in which the patient had higher than expected antibody titers against the Epstein-Barr (EBV) and rubella viruses. In addition, high anti-EBV titers in family members physically separated suggest an altered immunologic reactivity which could be important in the development of the massive lymphadenopathy associated with this syndrome. The relationship of this syndrome to the EBV along with its histologic characteristics suggest that it may represent a peculiar, late sequelae of infection with this virus, or an atypical manifestations of infectious mononucleosis in an immunologically defective individual.

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