𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Sinonasal neuroendocrine carcinoma in association with SIADH

✍ Scribed by Nilesh R. Vasan; Jesus E. Medina; Vikki A. Canfield; Elizabeth M. Gillies

Book ID
102847099
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
716 KB
Volume
26
Category
Article
ISSN
1043-3074

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✦ Synopsis

Abstract

Background. Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer.

Methods. We report a 30‐year‐old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy.

Results. Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH.

Conclusions. We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports. Β© 2004 Wiley Periodicals, Inc. Head Neck 26: 89–93, 2004

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