Sinonasal malignancies in children: A 10-year, single-institutional review

✍ Scribed by Jose P. Zevallos; Kunal S. Jain; Dianna Roberts; Adel El-Naggar; Ehab Y. Hanna; Michael E. Kupferman

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 323 KB
• Volume: 121
• Category: Article
• ISSN: 0023-852X
• DOI: 10.1002/lary.21793

✦ Synopsis

Objectives:

Sinonasal malignancies in children are rare, histologically diverse tumors that present diagnostic and management challenges. the purpose of this study is to review the experience of a single cancer center in the management of pediatric sinonasal malignancies.

Study design:

Retrospective review.

Methods:

Retrospective chart review.

Results:

Forty-four patients were identified. the median age was 12 years (range: 2-17), 54% were female, and the maxillary sinus was the most common primary site. facial swelling and pain were the most common presenting complaints. thirty-four patients (76%) in this series had paranasal sinus sarcomas, three patients had esthesioneuroblastomas, and eight patients had carcinomas. the 5-year overall survival, disease-specific survival, and recurrence rate for the entire group was 71%, 81%, and 43%, respectively.

Conclusions:

Pediatric sinonasal malignancies are rare, locally aggressive tumors associated with nonspecific signs and symptoms. multimodality treatment can result in 5-year overall and disease-specific survival rates of over 70%. a multidisciplinary team approach is essential to optimize outcomes and limit the morbidity of treatment.