Sinonasal adenoid cystic carcinoma : The M. D. Anderson Cancer Center experience

✍ Scribed by Allison D. Lupinetti; Dianna B. Roberts; Michelle D. Williams; Michael E. Kupferman; David I. Rosenthal; Franco Demonte; Adel El-Naggar; Randal S. Weber; Ehab Y. Hanna

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 410 KB
• Volume: 110
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/cncr.23096

✦ Synopsis

Abstract

BACKGROUND.

Adenoid cystic carcinoma of the sinonasal tract is a rare cancer that accounts for 10% of all malignancies at this site. The objective of the current study was to evaluate prognostic factors, treatment outcomes, recurrence patterns, and survival rates for sinonasal adenoid cystic carcinoma.

METHODS.

A retrospective chart review was performed at an academic tertiary referral center. Between 1990 and 2004, 105 patients were evaluated for adenoid cystic carcinoma of the sinonasal tract at a single institution. Demographics, presentation, anatomic site, Tumor, Lymph Node, Metastasis (TNM) classification, pathology, treatment, recurrences, and survival were evaluated.

RESULTS.

One hundred five patients with adenoid cystic carcinoma were evaluated, including 58 women and 47 men. Their median age was 50 years, and the mean follow‐up was 47 months. The maxillary sinus (47%) and the nasal cavity (30%) were the most common primary tumor sites. The majority of patients presented with T3/T4 (76.7%), N0 (98%), M0 (97%) disease. Eighty‐four percent of patients underwent surgery and received postoperative radiation as treatment for their primary disease. The local recurrence rate was 30%, and the distant metastases rate was 38%. The 5‐year overall survival and disease specific survival rates were 62.9% and 70.9%, respectively.

CONCLUSIONS.

Adenoid cystic carcinoma of the paranasal sinuses is a rare disease, and the ideal treatment paradigm has yet to be defined. The current data suggested that surgical resection with postoperative radiation therapy offers durable local control and compares favorably with historic data. Although local recurrences develop in a significant percentage of patients, survival from this disease exceeds that of other sinonasal malignancies. Cancer 2007. © 2007 American Cancer Society.