Singlet oxygen oxidation of pyrroles. Fo
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Harry H. Wasserman; Mingde Xia; Jianji Wang; Anders K. Petersen; Michael Jorgens
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Article
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1999
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Elsevier Science
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French
β 206 KB
The ten-butyl ester of 3-methoxy-2-pyrrolecarboxylic acid 3 undergoes reaction with singlet oxygen to form an intermediate imino hydroperoxide 4. This hydroperoxide may be trapped by a variety of nucleophiles yielding 5substituted pyrroles 6. With strong nucleophilic substituents at the 5-position,