Single signal of the Williams syndrome chromosome region 1 gene in hyperploidic bone marrow cells of acute lymphoblastic leukemia in a Williams syndrome patient

Amplification of the MLL gene on double

Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome

✍ Berthold Streubel; Peter Valent; Ulrich Jäger; Martin Edelhäuser; Hannes Wandt; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB 👁 2 views

Gene amplification is one of the mechanisms for activating proto-oncogenes resulting in an enhanced expression of the corresponding gene product. By fluorescence in situ hybridization (FISH), amplification of the proto-oncogene MLL has been described only in seven patients with acute myeloid leukemi