𝔖 Bobbio Scriptorium
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Single-sequence correlation chromatography A novel technique to decrease detection limits

✍ Scribed by D.J. Louwerse; H.F.M. Boelens; H.C. Smit


Book ID
102981592
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
864 KB
Volume
256
Category
Article
ISSN
0003-2670

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✦ Synopsis


A new method, bemg an mtermechate between smgle-mjectlon chromatography and conventIona correlation chromatography, LS described With respect to smgle-inJectIon chromatography, the mjection volume can be slgmficandy enlarged However, the rectangular Input function IS modulated with a fmestructure A deconvolutron procedure makes 11 possible to preserve a good peak resolution for the fast elutmg narrow peaks, while other more broadened peaks can be treated m a conventIonal way In both cases the signal-to-nmse ratlo IS Improved, and the detectIon hmlt 1s decreased

The theoretIca background IS presented, and the feasiblhty of the method 1s confumed by slmulatlon stuches and experiments Potentially, gradlent elutlon hqmd chromatography or programmed-temperature gas chromatography IS stdl apphcable, m contrast to conventIona correlation and multiplex techmques


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