Single-Quantum Coherence Filter for Strongly Coupled Spin Systems for Localized 1H NMR Spectroscopy
✍ Scribed by Andreas H Trabesinger; D.Christoph Mueller; Peter Boesiger
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 247 KB
- Volume
- 145
- Category
- Article
- ISSN
- 1090-7807
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✦ Synopsis
A pulse sequence for localized in vivo (1)H NMR spectroscopy is presented, which selectively filters single-quantum coherence built up by strongly coupled spin systems. Uncoupled and weakly coupled spin systems do not contribute to the signal output. Analytical calculations using a product operator description of the strongly coupled AB spin system as well as in vitro tests demonstrate that the proposed filter produces a signal output for a strongly coupled AB spin system, whereas the resonances of a weakly coupled AX spin system and of uncoupled spins are widely suppressed. As a potential application, the detection of the strongly coupled AA'BB' spin system of taurine at 1.5 T is discussed.