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Single photon emission tomography in Alzheimer's disease. A longitudinal study of changes in relative regional cerebral blood flow

✍ Scribed by Dr. Michael P. Philpot; Durval C. Costa; Alistair Burns; Raymond Levy; Peter J. Ell

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 618 KB
Volume: 6
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.930061103

No coin nor oath required. For personal study only.

✦ Synopsis

Relative regional cerebral blood (rCBF) was measured in 10 patients fulfilling NINCDS-ADRDA criteria for Alzheimer's disease using Tc-99m-HMPAO single photon emission tomography (SPET). In comparison with 1 1 age-matched control subjects, relative rCBF was reduced in lateral and medial temporal areas. SPET was repeated after 12-18 months. Relative rCBF fell significantly in the frontal and anterior and posterior parietal areas. Significant changes in lefthight asymmetry were found in the frontal and posterior parietal areas suggesting a greater reduction in left hemisphere rCBF. There were few associations between relative rCBF and neuropsychological test performance.

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