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Single Nucleotide Polymorphisms: Methods and Protocols

✍ Scribed by Barkur S. Shastry (auth.), Anton A. Komar (eds.)


Publisher
Humana Press
Year
2009
Tongue
English
Leaves
449
Series
Methods in Molecular Biologyβ„’ 578
Edition
2
Category
Library

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✦ Synopsis


In recent years, single nucleotide polymorphisms have received increased and special attention in a rapidly developing field of personalized medicine and drug treatment. Comprising more than eighty percent of all known polymorphisms, single nucleotide polymorphisms (SNPs) are primarily responsible for phenotypic differences between individuals, and have been suggested to affect the development of diseases in humans and the response to drug treatment and environmental stress. In Single Nucleotide Polymorphisms: Methods and Protocols, Second Edition, expert researchers explore the latest advances in this area, highlighting the substantial progress that has been made in SNP genotyping, examining recent developments in high-throughput genotyping approaches, and exploring our new understanding of the impact of SNPs on gene function. Chapters address the impact of SNPs on phenotype, examine SNP databases, look at methods that have been applied for SNP bioinformatics discovery and analysis, and discuss advanced experimental approaches used for SNP detection. Composed in the highly successful Methods in Molecular Biologyβ„’ series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls.

Current and innovative, Single Nucleotide Polymorphisms: Methods and Protocols,Second Edition is an essential guidebook for individual researchers as well as institutions and companies working in the field.

✦ Table of Contents


Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Front Matter....Pages 3-22
Front Matter....Pages 23-39
Front Matter....Pages 41-41
Front Matter....Pages 43-71
Front Matter....Pages 73-91
Front Matter....Pages 93-93
Front Matter....Pages 95-111
Back Matter....Pages 113-122
....Pages 123-133

✦ Subjects


Human Genetics; Gene Function


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Single Nucleotide Polymorphisms: Methods
✍ Lisa D. Brooks (auth.), Pui-Yan Kwok MD, PhD (eds.) πŸ“‚ Library πŸ“… 2003 πŸ› Springer New York 🌐 English

Single nucleotide polymorphisms (SNPs) have become the markers of choice in elucidating the relationship between DNA sequence variation and susceptibility to disease and have clearly become the focus of the next phase of the human genome project. In Single Nucleotide Polymorphisms: Methods and Proto