Single-nucleotide polymorphisms in tumor necrosis factor receptor genes: Definition of novel haplotypes and racial/ethnic differences

Linkage and association studies of singl

Linkage and association studies of single-nucleotide polymorphism–tagged tumor necrosis factor haplotypes in juvenile oligoarthritis

✍ Eleftheria Zeggini; Wendy Thomson; Dominic Kwiatkowski; Anna Richardson; William 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB

## Abstract ## Objective The presence of increased levels of tumor necrosis factor (TNF) in serum and synovial fluid of patients and the encouraging outcome of anti‐TNF therapy have implicated TNFα in the etiopathogenesis of juvenile oligoarthritis. Although the locus is polymorphic, no study has