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Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers

✍ Scribed by Vera Pravica; Dusan Popadic; Emina Savic; Milos Markovic; Jelena Drulovic; Marija Mostarica-Stojkovic

Book ID: 113093320
Publisher: Springer-Verlag
Year: 2012
Tongue: English
Weight: 274 KB
Volume: 52
Category: Article
ISSN: 0257-277X
DOI: 10.1007/s12026-012-8273-y

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## Abstract ## Objective Gene–gene interaction, or epistasis, is considered a ubiquitous component of complex human diseases such as systemic sclerosis (SSc). Epistasis is difficult to model by traditional parametric approaches; therefore, nonparametric computational algorithms, such as multifacto