Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption
✍ Scribed by Joke Werbrouck; Kim De Ruyck; Fréderic Duprez; Marc Van Eijkeren; Ernst Rietzschel; Sofie Bekaert; Anne Vral; Wilfried De Neve; Hubert Thierens
- Book ID
- 116759496
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 190 KB
- Volume
- 656
- Category
- Article
- ISSN
- 1383-5718
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## Abstract Squamous cell carcinoma of the head and neck (SCCHN), which is relatively prevalent in Korea, is believed to be induced by environmental carcinogens and host genetic factors. Accumulating evidence has shown that genetic differences in DNA repair capacity resulting from genetic polymorph
## Abstract Laryngeal cancer is known to be associated with smoking and high alcohol consumption. Nucleotide excision repair (NER) plays a key role in repairing DNA damage induced by these exposures and might affect laryngeal cancer susceptibility. In a population‐based case‐control study including