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Single nucleotide polymorphism D1853N of theATMgene may alter the risk for breast cancer

✍ Scribed by M. Schrauder; S. Frank; P. L. Strissel; M. P. Lux; M. R. Bani; C. Rauh; C. C. Sieber; K. Heusinger; A. Hartmann; R. Schulz-Wendtland; R. Strick; M. W. Beckmann; Peter A. Fasching

Book ID: 106123826
Publisher: Springer-Verlag
Year: 2008
Tongue: English
Weight: 426 KB
Volume: 134
Category: Article
ISSN: 1432-1335
DOI: 10.1007/s00432-008-0355-9

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## Abstract The gene coding for the human homologue of the __Drosophila__ segment polarity gene __patched__ (PTCH1) is mutated in several common human tumors. In mice, haplodeficiency at the __Ptch1__ locus results in severe histologic defects in mammary ductal structure. We found no mutations with