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Single-Molecule Insights on Human RNA Polymerase II Transcription Regulation: Assembly of the Pre-Initiation Complex and the Roles of Activators

✍ Scribed by Zhang, Zhengjian; Revyakin, Andrey; Coleman, Robert; Chu, Steve; Tjian, Robert


Book ID
122312125
Publisher
Biophysical Society
Year
2013
Tongue
English
Weight
55 KB
Volume
104
Category
Article
ISSN
0006-3495

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## Abstract The human dhfr minor transcript is distinguished from the predominant dhfr mRNA by an ∼400 nucleotide extension of the 5′‐untranslated region, which corresponds to the major (core) promoter DNA (its template). Based on its unusual sequence composition, we hypothesized that the minor tra